Rapidly get hold of sections as skinny or thick as your software involves, with out worrying about shedding or distorting important tissue samples.
Megatome can be a vibrating microtome built to portion a wide variety of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With significant blade vibrating frequency and minimized blade deflection, Megatome enables large-throughput tissue sectioning with uniform surface area profile, and also small tissue destruction and knowledge decline.
Antibodies might consider weeks to diffuse via only a few millimeters of tissue, having a steep labeling gradient from area to Main.
Megatome is suitable for precision: the blade vibrates at an increased frequency and bigger amplitude selection than other microtomes, and contains a exceptional deflection Regulate system.
SE takes advantage of a rotational electric powered subject to disperse really electromobile molecules (which include antibodies or surfactant micelles) in the course of a porous sample devoid of detrimental electrically charged structures throughout the tissue. This allows two-4 working day clearing of intact organs,
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Megatome is actually a novel microtome that allows for top-precision sectioning of a variety of tissue samples – from organoids, to arrays of animal organs, to intact human Mind hemispheres – with minimum tissue damage and data loss.
It’s time for you to enhance megatomi.com your microtome to Megatome. With precise higher-frequency slicing for an unmatched choice of sample sizes and kinds – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for numerous apps.
The SmartSPIM light sheet microscope delivers unparalleled resolution and acquisition speed all over intact tissue volumes, although its modular structure lets you upgrade and personalize individual parts.
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Protect avoids the variability of hydrogel embedding and the data loss from PFA preservation, safeguarding specimens for many rounds of processing.
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Our novel Protect tissue preservation technique types intramolecular bonds making use of polyfunctional, versatile epoxides to stabilize tissue architecture and safeguard the sample’s endogenous fluorescence, protein antigenicity and nucleic acids.